Bioactive Lignans from the Rhizomes of <i>Acorus gramineus</i>

Abstract

As a part of our ongoing search for bioactive constituents from natural Korean sources, the investigation of rhizomes of <i>Acorus gramineus</i> afforded five new lignans, named ligraminols A–E (<b>1</b>–<b>5</b>), together with seven known ones (<b>6</b>–<b>12</b>). The structures of <b>1</b>–<b>5</b> were determined by a combination of 1D and 2D NMR, HRMS, CD, and enzymatic hydrolysis. Compounds <b>1</b>–<b>12</b> were tested for their antiproliferative activities toward a panel of human-derived normal and cancer cell lines. Moreover, compounds <b>1</b>–<b>12</b> were evaluated for their inhibitory activities on nitric oxide production in an activated murine microglial cell line