Canonical pathways associated with blood transcripts that are differentially expressed in <i>L</i>. <i>monocytogenes</i> infected <i>Ifnar1</i>^-/- versus WT mice against control uninfected <i>Ifnar1</i>^-/- mice.

Abstract

<p>Top IPA® canonical pathways that are associated with differentially expressed blood day 1, day 2 and day 3 transcripts from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150251#pone.0150251.g003" target="_blank">Fig 3B</a> and pass a further 1.5-fold change filter ratio between <b>(A)</b> WT infected to KO uninfected; <b>(B)</b> KO infected to KO uninfected; and <b>(C)</b> (KO infected to KO uninfected) as compared to (WT infected to KO uninfected). Percent pathway modulation relative to each dataset and pathway size is indicated in red for up-regulated and blue for down-regulated genes. Pathway rank for pathways passing <i>p<0</i>.<i>05</i> after Fisher’s Exact test at each time-point is marked. <b>(D and E)</b> Detailed heat map of differentially expressed genes found in the <b>(D)</b> Interferon Signaling Pathway; and <b>(E)</b> Antigen Presentation Pathway.</p