Additional file 1: Figure S1. of Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
Tau pathology observed with the Tau/pS422 antibody. a-f Immunofluorescence staining against hyperphosphorylated tau (Tau/pS422) in human brain samples. Intense immunoreactivity in FAD, CBD and PSP. a FAD cases show immunoreactivity in neurofibrillary tangles, pretangles, neuropil threads and dystrophic neurites. b-c CBD and PSP cases show immunoreactivity in neurons and glial cells. d-f High magnification of the boxed areas in a-c. Scale bars: 50 μm (10 μm high magnification) (TIF 3632 kb
