<p>LPS (1 μg /1 μl) or saline (1 μl) was locally injected into substantia nigra. One day and five days later, mice were sacrificed respectively. (A) Immunohistochemical images of substantia nigra showed the differential loss of TH-positive neurons in WT (upper panel) and DJ-1 KO (lower panel) mice Day 1 (left 4 images) or Day 5 (right 4 images) after local injection of LPS. Note that LPS-induced death of dopaminergic neurons was enhanced on Day 5 in DJ-1 KO mice. The statistical results were shown in (B). The mean of the summated neuron number was shown in each group and the data are presented as mean ± S.E.M. (n = 7 for each group) * p<0.05, Scale bar: 0.25 mm.</p
