Synthesis and functionalization of 92S bioactive glasses for drug delivery system

Abstract

<p>A new glass formulation, with the molar composition 92% SiO<sub>2</sub>– 6 % CaO – 2% P<sub>2</sub>O<sub>5</sub> was synthesized using the sol-gel process, for applications as biomaterial in orthopaedic or maxillo facial surgery. Pellets, made of glass powder, were uniaxially compacted and soaked  in Simulated Body Fluid (SBF) for up to 7 days at 37°C to evaluate glass bioactivity. Ionic exchanges  at the interface glass-SBF were evaluated by studying evolutions of calcium, phosphorus and  silicon concentrations in SBF using ICP-OES. Changes in glass surface, and the formation of crystalline phases were analyzed using XRD, SEM, EDS and FTIR methods. In the pharmaceutical field, these materials are particularly interesting for the synthesis of drugs for controlled release. </p

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