<p>(A) Top five most significant enriched canonical pathways identified by Ingenuity Pathway Analysis (grey bars) using all the differentially expressed genes in LDR vs ND, HDR vs LDR and HDR vs ND islets comparisons that are listed according to their p-values expressed in—log (Y axis). The ratio of the number of differentially expressed genes over the total number of genes involved in each canonical pathway is reported on top of the bars. (B) AMPK pathways, (C) mitochondrial respiration, (D) mitochondrial metabolism and (E) cholesterol metabolism and trafficking gene expression by microarray analysis (B, C, D and E; +/- 1.2 fold change) and quantitative real time PCR (B; +/- 1.15 fold change) of HDR vs LDR (gray bar) and HDR vs ND (white bar).</p
