MOESM1 of Hydroxyurea down-regulates BCL11A, KLF-1 and MYB through miRNA-mediated actions to induce γ-globin expression: implications for new therapeutic approaches of sickle cell disease
Additional file 1: Figure S1. Time dependent expression of markers of late erythroid differentiation (CD235a and CD71) in erythroid cells treated with HU. Expression of CD235a (A) and CD71 (B) during late erythroid differentiation show no significant differences between HU treated (+) and untreated (−) cells. The lack of significant changes in the expression of these markers is indicates that HU had minimal effect on the processes of erythroid differentiation, thus suggesting that the results, particularly the induction of γ-globin and repression of BCL11A, KLF-1 and MYB, were not artefacts of stress erythropoiesis
