Additional file 1: Table S1. Characterization of Resveratrol-loaded SLNs: SLN placebo and SLN-Resveratrol (2, 5, 10 and 15 mg of resveratrol). Figure S1. Effect of time of storage on particle size of RSV loaded SLNs with different amounts of RSV. Figure S2. Effect of time of storage on zeta potential of RSV loaded SLNs with different amounts of RSV. Figure S3. Effect of time of storage on entrapment efficiency of RSV loaded SLNs with different amounts ofRSV. Figure S4. In vitro RSV release profiles from RSV loaded SLNs with different amounts of RSV performed in SBF, simulating the blood stream conditions, at body temperature (37 ÂşC). Figure S5. Images of hCMEC/D3 cells on transwell devices during the 7 days of growing