<p>(A-B) Regeneration of megakaryocytes in response to platelet reduction was evident with larger megakaryocytes with irregular multilobulated nucleus and more prominent nucleoli in spleen and bone marrow respectively. (C-D) Mean megakaryocyte volume represented by Leishman-Giemsa positive cells (per field@400×) in spleen (<i>n</i> = 60) and bone marrow (<i>n</i> = 120) respectively. (E) Pneumonitis caused due to extensive proliferation of lymphocytes in the peribronchial region (br, bronchiole). (F) Hepatic tissue reports centrilobular necrosis characterized by prominent ballooning, swollen granular cytoplasm with fading nuclei and nuclear infiltration (cv, central vein). (G) Mild acute renal tubular necrosis illustrated by destroyed cells in proximal tubules (pr). (H) Toluidine blue-positive mast cells (inset red arrow) scattered in lung tissue. (I) Mean mast cell recruitment (per field@400×) in lung tissue of control and toxin groups (<i>n</i> = 120). Asterisks indicate significant difference, <i>t</i>-test, <i>P <</i> 0.05. Fig A,B = magnification 1000× and scale bar = 8 <i>μ</i>m. Fig E-G = 200× and 100 <i>μ</i>m. Fig H = 400× and 20 <i>μ</i>m.</p
