ICC of DNA modification for the 82 disease-specific differentially modified loci (p < 0.05). The Z-scores are normalized ICC coefficients, where positive Z-scores represent ICC coefficients that are higher than the mean, while negative Z-scores show the opposite. Cumulative Z-scores for normalized ICC coefficients represent the following: 0 % includes none, 50 % includes half, and 100 % includes all Z-scores. a Approximately 90 % of Z-scores are positive in the comparison of the EAO AD cortex samples versus cerebellum (CB) but only ~25 % of Z-scores are positive in the LAO versus cerebellum, indicating a more advanced state of dedifferentiation for EAO AD cortices. LAO versus EAO show an even distribution. b Buccal cell analysis showed that ~75 % AD twins, but only ~50 % of their healthy co-twins, had higher than average similarity as measured by Z-scores of ICC. (PDF 123 kb
