Risk of Wheezing Attacks in Infants With Transient Tachypnea Newborns

Abstract

<div>Background: The most common reason of respiratory distress in the newborn is transient tachypnea of the newborn (TTN). There are </div><div>some reports saying that TTN is associated with increased frequencies of wheezing attacks.</div><div>Objectives: The aims of this study were to determine the risk factors associated with TTN and to determine the association between TTN </div><div>and the development of wheezing syndromes in early life.</div><div>Materials and Methods: In a historical cohort study, we recorded the characteristics of 70 infants born at the Shohadaye Kargar Hospital </div><div>in Yazd between March 2005 and March 2009 and who were hospitalized because of TTN in the neonatal intensive-care unit. We called </div><div>their parents at least four years after the infants were discharged from the hospital and asked about any wheezing attacks. Seventy other </div><div>infants with no health problems during the newborn period were included in the study as the control group.</div><div>Results: The rate of wheezing attacks in newborns with TTN was more than patients with no TTN diagnosis (P = 0.014). TTN was found to </div><div>be an independent risk factor for later wheezing attacks (relative risk [RR] = 2.8).</div><div>Conclusions: The most obvious finding of this study was that TTN was an independent risk factor for wheezing attacks. So long-term </div><div>medical care is suggested for these patients who may be at risk, because TTN may not be as transient as has been previously thought.</div