NMR instruments equipped
with multiple receivers can significantly increase the information content in
experiments by recording multiple free induction decays (FID-s) from several
nuclear species in a single pass. This in turn reduces the number of
experiments required to solve a particular analytical or structure elucidation
problem. We present a comprehensive series of such experiments that involve
multi-receiver detection of two of the most sensitive NMR nuclei β <sup>1</sup>H
and <sup>19</sup>F. The experiment designs are categorized into three main
groups β (i) interleaved experiments, (ii) parallel acquisition experiments and
(iii) sequential acquisition experiments. The interleaved experiments are based
on independent pulse programs that are typically dealing with more or less
isolated spin systems and avoid perturbing spin system(s) that are recovering
while the experiment involving the active spin system is conducted. The
parallel acquisition experiments are based on simultaneous observation of the
free induction decays (FID-s) of several spin systems in parallel. The
multi-dimensional experiments of this type usually involve joint coherence
transfer pathways and one or more joint frequency domains. Finally, the
sequential acquisition experiments involve direct observation of one or more FID-s
within the pulse sequence and otherwise are similar to the parallel acquisition
experiments. Several examples of each type of multi-receive H/F experiments
involving the most popular NMR pulse sequences including COSY, TOCSY, DOSY,
HOESY, HETCOR, HSQC, HMQC, HMBC and T<sub>1</sub> measurement by inversion
recovery method are presented and discussed. Furthermore, we demonstrate that
efficiency of such experiments can be further improved by combining the
multi-receiver methodology with the modern approaches of fast methods, such as
relaxation optimization, non-uniform sampling, Hadamard encoding,
computer-optimized folding and ultra-fast NMR by spatial encoding. We believe
that the multi-receiver technology is set to become a routine way of
multiplying the efficiency and throughput in high-resolution NMR spectroscopy