<p>Mandatory Folic Acid (FA) fortification of staple foods<br>in a number of countries and periconceptional supplementation has led to increased levels of FA intake. There is ongoing controversy over the effect of FA supplementation on cancer risk, with high levels of FA (≥400ug/day) associated with an increased risk of breast cancer. FA is thought to infer cancer risk through modulation of the epigenome. Here, we investigated whether variations in FA intake<br>during adulthood induced persistent changes in the<br>expression of the tumour suppressor gene Brca1 and<br>the pluripotency gene Oct-4, which play key roles in<br>DNA repair and cellular differentiation.</p
