Adam, Gerhard

Hofmann, Martin

Ittrich, Harald

Jung, Caroline

Kaul, Michael

Knopp, Tobias

Nielsen, Peter

Reimer, Rudolph

Salamon, Johannes

Them, Kolja

Vom Scheidt, Annika

Werner, Franziska

Yamamoto, Masaya

<div>PurposeIn-vitro evaluation of the feasibility of 4D real time tracking of endovascular devices and stenosis treatment with a magnetic particle imaging (MPI) / magnetic resonance imaging (MRI) road map approach and an MPI-guided approach using a blood pool tracer.Materials and MethodsA guide wire and angioplasty-catheter were labeled with a thin layer of magnetic lacquer. For real time MPI a custom made software framework was developed. A stenotic vessel phantom filled with saline or superparamagnetic iron oxide nanoparticles (MM4) was equipped with bimodal fiducial markers for co-registration in preclinical 7T MRI and MPI. In-vitro angioplasty was performed inflating the balloon with saline or MM4. MPI data were acquired using a field of view of 37.3×37.3×18.6 mm3 and a frame rate of 46 volumes/sec. Analysis of the magnetic lacquer-marks on the devices were performed with electron microscopy, atomic absorption spectrometry and micro-computed tomography.ResultsMagnetic marks allowed for MPI/MRI guidance of interventional devices. Bimodal fiducial markers enable MPI/MRI image fusion for MRI based roadmapping. MRI roadmapping and the blood pool tracer approach facilitate MPI real time monitoring of in-vitro angioplasty. Successful angioplasty was verified with MPI and MRI. Magnetic marks consist of micrometer sized ferromagnetic plates mainly composed of iron and iron oxide.Conclusions4D real time MP imaging, tracking and guiding of endovascular instruments and in-vitro angioplasty is feasible. In addition to an approach that requires a blood pool tracer, MRI based roadmapping might emerge as a promising tool for radiation free 4D MPI-guided interventions.</div

Johannes Salamon (333205)

Martin Hofmann (2818252)

Caroline Jung (323647)

Michael Gerhard Kaul (2818249)

Franziska Werner (551407)

Kolja Them (2818261)

Rudolph Reimer (190562)

Peter Nielsen (323646)

Annika vom Scheidt (2818255)

Gerhard Adam (645067)

Tobias Knopp (2818258)

Harald Ittrich (291027)

FigShare

Magnetic Particle / Magnetic Resonance Imaging: In-Vitro MPI-Guided Real Time Catheter Tracking and 4D Angioplasty Using a Road Map and Blood Pool Tracer Approach

In-vitro evaluation of the feasibility of 4D real time tracking of endovascular devices and stenosis treatment with a magnetic particle imaging (MPI) / magnetic resonance imaging (MRI) road map approach and an MPI-guided approach using a blood pool tracer

Open Access Repository Technischen Universität Hamburg

PLoS ONE

Magnetic particle / magnetic resonance imaging: in-vitro MPI-guided real time catheter tracking and 4D angioplasty using a road map and blood pool tracer approach

TUHH Open Research (TORE)

PURPOSE:In-vitro evaluation of the feasibility of 4D real time tracking of endovascular devices and stenosis treatment with a magnetic particle imaging (MPI) / magnetic resonance imaging (MRI) road map approach and an MPI-guided approach using a blood pool tracer. MATERIALS AND METHODS:A guide wire and angioplasty-catheter were labeled with a thin layer of magnetic lacquer. For real time MPI a custom made software framework was developed. A stenotic vessel phantom filled with saline or superparamagnetic iron oxide nanoparticles (MM4) was equipped with bimodal fiducial markers for co-registration in preclinical 7T MRI and MPI. In-vitro angioplasty was performed inflating the balloon with saline or MM4. MPI data were acquired using a field of view of 37.3×37.3×18.6 mm3 and a frame rate of 46 volumes/sec. Analysis of the magnetic lacquer-marks on the devices were performed with electron microscopy, atomic absorption spectrometry and micro-computed tomography. RESULTS:Magnetic marks allowed for MPI/MRI guidance of interventional devices. Bimodal fiducial markers enable MPI/MRI image fusion for MRI based roadmapping. MRI roadmapping and the blood pool tracer approach facilitate MPI real time monitoring of in-vitro angioplasty. Successful angioplasty was verified with MPI and MRI. Magnetic marks consist of micrometer sized ferromagnetic plates mainly composed of iron and iron oxide. CONCLUSIONS:4D real time MP imaging, tracking and guiding of endovascular instruments and in-vitro angioplasty is feasible. In addition to an approach that requires a blood pool tracer, MRI based roadmapping might emerge as a promising tool for radiation free 4D MPI-guided interventions

Johannes Salamon

Martin Hofmann

Caroline Jung

Michael Gerhard Kaul

Franziska Werner

Kolja Them

Rudolph Reimer

Peter Nielsen

Annika Vom Scheidt

Gerhard Adam

Tobias Knopp

Harald Ittrich

Directory of Open Access Journals

Magnetic Particle / Magnetic Resonance Imaging: In-Vitro MPI-Guided Real Time Catheter Tracking and 4D Angioplasty Using a Road Map and Blood Pool Tracer Approach.

https://figshare.com/articles/Magnetic_Particle_Magnetic_Resonance_Imaging_i_In-Vitro_i_MPI-Guided_Real_Time_Catheter_Tracking_and_4D_Angioplasty_Using_a_Road_Map_and_Blood_Pool_Tracer_Approach/3418828