<p>Parameter sensitivity analysis for parameters related to postprandial insulin dynamics; (A,C,E) Predicted plasma glucose concentrations (mM) (B,D,F). Predicted plasma insulin concentrations (ng/ml).</p

Harma Berends (2814478)

Jayden A. R. MacPherson (2814472)

John P. Cant (2814481)

Michael A. Steele (458410)

Priska Stahel (2814475)

PubMed

Parameter sensitivity analysis for postprandial first order gastric emptying rate while maintaining a constant ratio of kSP,2: kSP,3;; (A) Predicted plasma glucose concentrations (mM). (B). Predicted plasma insulin concentrations (ng/ml).</p

The Francis Crick Institute

A Mechanistic Model of Intermittent Gastric Emptying and Glucose-Insulin Dynamics following a Meal Containing Milk Components - Fig 4

Priska Stahel

John P. Cant

Jayden A. R. MacPherson

Harma Berends

Michael A. Steele

Crossref

PLoS ONE

A Mechanistic Model of Intermittent Gastric Emptying and Glucose-Insulin Dynamics following a Meal Containing Milk Components

Parameter sensitivity analysis for parameters related to postprandial glucose dynamics; (A,C,E,G) Predicted plasma glucose concentrations (mM). (B,D,F,H). Predicted plasma insulin concentrations (ng/ml).</p

A Mechanistic Model of Intermittent Gastric Emptying and Glucose-Insulin Dynamics following a Meal Containing Milk Components - Fig 5

To support decision-making around diet selection choices to manage glycemia following a meal, a novel mechanistic model of intermittent gastric emptying and plasma glucose-insulin dynamics was developed. Model development was guided by postprandial timecourses of plasma glucose, insulin and the gastric emptying marker acetaminophen in infant calves fed meals of 2 or 4 L milk replacer. Assigning a fast, slow or zero first-order gastric emptying rate to each interval between plasma samples fit acetaminophen curves with prediction errors equal to 9% of the mean observed acetaminophen concentration. Those gastric emptying parameters were applied to glucose appearance in conjunction with minimal models of glucose disposal and insulin dynamics to describe postprandial glycemia and insulinemia. The final model contains 20 parameters, 8 of which can be obtained by direct measurement and 12 by fitting to observations. The minimal model of intestinal glucose delivery contains 2 gastric emptying parameters and a third parameter describing the time lag between emptying and appearance of glucose in plasma. Sensitivity analysis of the aggregate model revealed that gastric emptying rate influences area under the plasma insulin curve but has little effect on area under the plasma glucose curve. This result indicates that pancreatic responsiveness is influenced by gastric emptying rate as a consequence of the quasi-exponential relationship between plasma glucose concentration and pancreatic insulin release. The fitted aggregate model was able to reproduce the multiple postprandial rises and falls in plasma glucose concentration observed in calves consuming a normal-sized meal containing milk components

John P Cant

Jayden A R MacPherson

Michael A Steele

Directory of Open Access Journals

A Mechanistic Model of Intermittent Gastric Emptying and Glucose-Insulin Dynamics following a Meal Containing Milk Components.

To support decision-making around diet selection choices to manage glycemia following a meal, a novel mechanistic model of intermittent gastric emptying and plasma glucose-insulin dynamics was developed. Model development was guided by postprandial timecourses of plasma glucose, insulin and the gastric emptying marker acetaminophen in infant calves fed meals of 2 or 4 L milk replacer. Assigning a fast, slow or zero first-order gastric emptying rate to each interval between plasma samples fit acetaminophen curves with prediction errors equal to 9% of the mean observed acetaminophen concentration. Those gastric emptying parameters were applied to glucose appearance in conjunction with minimal models of glucose disposal and insulin dynamics to describe postprandial glycemia and insulinemia. The final model contains 20 parameters, 8 of which can be obtained by direct measurement and 12 by fitting to observations. The minimal model of intestinal glucose delivery contains 2 gastric emptying parameters and a third parameter describing the time lag between emptying and appearance of glucose in plasma. Sensitivity analysis of the aggregate model revealed that gastric emptying rate influences area under the plasma insulin curve but has little effect on area under the plasma glucose curve. This result indicates that pancreatic responsiveness is influenced by gastric emptying rate as a consequence of the quasi-exponential relationship between plasma glucose concentration and pancreatic insulin release. The fitted aggregate model was able to reproduce the multiple postprandial rises and falls in plasma glucose concentration observed in calves consuming a normal-sized meal containing milk components.</div

Parameter sensitivity analysis for parameters related to postprandial insulin dynamics; (A,C,E) Predicted plasma glucose concentrations (mM) (B,D,F). Predicted plasma insulin concentrations (ng/ml).</p

A Mechanistic Model of Intermittent Gastric Emptying and Glucose-Insulin Dynamics following a Meal Containing Milk Components - Fig 6

https://figshare.com/articles/A_Mechanistic_Model_of_Intermittent_Gastric_Emptying_and_Glucose-Insulin_Dynamics_following_a_Meal_Containing_Milk_Components_-_Fig_6/3411868

10. D40TA使用経験(第513回千葉医学会第5回麻酔科例会第10回千葉麻酔懇談会)

Abstract

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The Francis Crick Institute

Crossref

The Francis Crick Institute

Directory of Open Access Journals

The Francis Crick Institute

The Francis Crick Institute

10. D40TA使用経験(第513回千葉医学会 第5回麻酔科例会 第10回千葉麻酔懇談会)

Abstract

Similar works

Full text

Available Versions

The Francis Crick Institute

Crossref

The Francis Crick Institute

Directory of Open Access Journals

The Francis Crick Institute

The Francis Crick Institute

10. D40TA使用経験(第513回千葉医学会第5回麻酔科例会第10回千葉麻酔懇談会)