Measurement of pausing index (PI). Figure S2. Robustness of RNAP2 pausing calculations. Figure S3. Pausing across cell and tissue types. Figure S4. Correlation between pausing and promoter GC and CpG content Figure S5. Relationship between whole gene, TSSR, and gene body RNAP2 density and PI to gene expression for GM12878, H1, K562, IMR90, HUVEC, and HepG2 cells. Figure S6. Grouping paused and non-paused genes by mean population-wide expression shows no consistent expression level difference within quantile. Figure S7. Effect of extracellular stimuli on RNAP2 pausing. Figure S8. Relationship of gene expression to TSSR and gene body RNAP2 density and to PI. Figure S9. The inflection point does not appear to be driven by a limit to the level of initiating RNAP2. Figure S10. Nucleosome positioning and RNAP2 pausing. Figure S11. Chromatin features and RNAP2 pausing. (PDF 7287 kb
