Functional
polystyrenes and polyacrylamides, containing combinations
of fluorosulfate, aromatic silyl ether, and azide side chains, were
used as scaffolds to demonstrate the postpolymerization modification
capabilities of sulfur(VI) fluoride exchange (SuFEx) and CuAAC chemistries.
Fluorescent dyes bearing appropriate functional groups were sequentially
attached to the backbone of the copolymers, quantitatively and selectively
addressing their reactive partners. This combined SuFEx and CuAAC
approach proved to be robust and versatile, allowing for a rare accomplishment:
triple orthogonal functionalization of a copolymer under essentially
ambient conditions without protecting groups
