Asymmetric Synthesis of CF<sub>3</sub>- and Indole-Containing
Thiochromanes via a Squaramide-Catalyzed Michael–Aldol Reaction
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Abstract
A Michael–aldol
reaction of 2-mercaptobenzaldehyde with
β-indole-β-CF<sub>3</sub> enones catalyzed by a squaramide
has been realized. The method affords a series of 2-CF<sub>3</sub>-2-indole-substituted thiochromanes featuring a CF<sub>3</sub>-containing
quaternary stereocenter in excellent yields, diastereoselectivities,
and enantioselectivities
