<p>Glycemia <b>(A)</b> and insulinemia <b>(B)</b> were measured after glucose administration at time 0 in ND or HFD-fed NN and NJ mice and area under the curve (AUC) was calculated for glycemia <b>(D)</b> and insulinemia <b>(E)</b> curves. Glycemia during ITT and area above the curve (AAC) <b>(C and F)</b> in NN or NJ mice fed a HFD. Results are means ± SEM of 7–9 mice in 2–3 independent experiments. Glycemia was also measured after glucose administration in HFD-fed NN and NJ WT <b>(G)</b> or MCre <b>(H)</b> mice. In the same OGTT tests, insulinemia was measured in NN and NJ WT <b>(I)</b> or MCre <b>(J)</b> mice. Insets depict AUC for glycemia and insulinemia curves. Results are means ± SEM of 3 WT and 6 MCre mice/group in 2–3 independent experiments. *p<0.05 and **p<0.01 compared to NN mice under the same diet (two-way ANOVA and Bonferroni post hoc test or Student’s t-test).</p
