<p>Insulin secretion at 3 mM glucose plus 35 mM KCl and at 3, 8 and 16 mM glucose in the absence (3G, 8G and 16G) <b>(A)</b> or the presence <b>(B)</b> of palmitate/oleate (OP; 0.15mM each) (3G/OP, 8G/OP and 16G/OP) (n = 4–5 mice, 3–4 replicates/mouse). Insulin release was normalized for the total islet insulin content. Insulin content/10 islets <b>(C)</b>, pancreas weight <b>(D)</b> and beta-cell mass <b>(E)</b> of HFD-fed NN or NJ mice. Results are means ± SEM of 2–3 independent experiments. *p<0.05 and **p<0.01 compared to NN mice (Student’s t-test).</p
