<p>An efficient, easy-to-handle, and mild substitution reaction approach has been developed for the synthesis of phosphonate derivatives, which are very important in the field of industrial, agricultural, and medicinal chemistry. A large number of nucleophiles, including arylamines, alkylamines, heteroarylamines, primary amines and secondary amines, sulfides, and carbides were attempted to react with α-tosyloxyphosphonate <b>1</b>. The reaction proceeded under catalyst-free and neat conditions and the corresponding phosphonates <b>2</b> were afforded in good yields.</p
