Immunization with 17D-204 protects mice against cytokine storm associated with virulent wtYFV infection.

Abstract

<p>5–6 week old mice received 17D-204 immunization or mock vaccination. Mice in the groups receiving Ang71 were infected on d21 after 17D-204 immunization, at approximately 8–9 weeks of age. On the indicated days p.i., serum was harvested and cytokine levels were determined by multiplex Luminex bead assay. Mock groups were collected at a 4d p.i. only. Samples for the Ang71 group were collected on d2, d4, and d5 p.i. Samples for the 17D-204-Ang71 group were collected on d1, d2, d3, and d4 p.i. Samples were collected from three separate experiments. Displayed data are n = 5 for mock, n = 3 for the other groups.</p

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