A simulation method is presented for the fatigue analysis of automotive and other products that are subjected to multiple random excitations. The method is denoted as frequency domain stress-life fatigue analysis and was implemented in the automotive industry at DAF Trucks N.V. in Eindhoven, The Netherlands. As an example case, a chassis part is analysed. The results of the analysis are consistent with fatigue cracks encountered during testing, which illustrates the effectiveness of the adopted method in the automotive industry