Cytoscape Network Showing the Connections between Phenotypes, the Genes with SNPs, and Pathways.

Abstract

<p>In this network, green squares represent phenotype; red triangles represent genes; and blue circles are KEGG pathways. The colored lines highlight the link between phenotype and pathway. For the gene <i>HLA-DRA</i> with SNPs associated with “<i>714</i>: <i>rheumatoid arthritis</i>” and “<i>250</i>: <i>type 1 diabetes</i>” is present in the KEGG pathway of “<i>rheumatoid arthritis</i>” (red line) and “<i>type 1 diabetes”</i> (green line) respectively. Also, the blue edge shows the connection between <i>“714</i>: <i>rheumatoid arthritis”</i>, <i>“716</i>: <i>other specified arthropathies”</i> and the KEGG “<i>JAK-STAT signaling pathway</i>” through two interleukin genes, <i>IL23R</i> and <i>IL6</i>.</p