The structure proposed for apteniol D is different from that of the compound obtained by total synthesis

Abstract

<p>We describe the synthesis of 4,4′-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4′-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in <i>N,N</i>-dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D.</p