<i>Setd7</i><sup>ΔIEC</sup> mice do not have increased resistance against infection with <i>H</i>. <i>p</i>. <i>bakeri</i>.

Abstract

<p>(A) <i>Setd7</i><sup>f/f</sup> and <i>Setd7</i><sup>ΔIEC</sup> mice were infected with ~ 200 <i>H</i>. <i>p</i>. <i>bakeri</i> eggs and were killed day 28 post infection. Worm burdens were determined microscopically from the small intestine. (B) Mesenteric lymph node (mLN) cell counts from naïve and <i>H</i>. <i>p</i>. <i>bakeri</i> infected mice (day 28 post infection). (C) Gene expression of indicated genes in small intestine (SI) that was adjacent to infection site at day 28 post infection with <i>H</i>. <i>p</i>. <i>bakeri</i>. Expression is relative to naïve mice (white bars). (D) Periodic acid-Schiff (PAS) staining of small intestinal tissue sections of indicated mice at day 28 post infection. Bar = 100 μm. (E) PAS+ cells per villus were counted from images as shown in (D). (A-E) n = 3 (naives), n = 8 (infected) from 2 independent experiments. <i>Setd7</i><sup>f/f</sup> black bars, <i>Setd7</i><sup>ΔIEC</sup> grey bars.</p

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