MOESM7 of Contribution of type W human endogenous retroviruses to the human genome: characterization of HERV-W proviral insertions and processed pseudogenes
Additional file 7: Fig. S6. MSRV Env puteins analysis with respect to the most similar HERV-W loci Env puteins and Syncytin-1 (locus 7q21.2). In Syncytin-1 ORF the domains mostly involved in the protein structure and function are annotated: Leader Peptide (LP), Binding Domain motif (BD), SU and TM disulphide bounds motifs (dS), Furin cleavage site (FCS), fusion core N- and C- terminal Heptad Repeats (NHR and CHR), Immunosuppressive domain (IM), Transmembrane unit (TM), Intracytoplasmic Tail (CYT) and the relative Syncytin-1 specific deletion (LQMV del). In Env puteins amino acid substitutions and internal stop codons with respect to Syncytin-1 are labeled with colored and black squares, respectively. The reading frames are reported below each sequence with a number and an arrow. The orange arrow indicates the Env portion frequently maintained in presence of flanking huge recurrent deletions
