<p>The horizontal axis lists the model’s parameters grouped by the sub-model. Parameters for the PBPK model start with “pbpk_”, the sinusoid models with “cc3d_” and the subcellular model with “sc_”. The vertical axis lists the model’s outputs duplicated for each of the input parameter sets. The “Average” row is the average of all the sensitivities in the column for the particular parameter set. Each square in the heat map is the relative change of a model output divided by the relative change of the model parameter in single-parameter-variation simulation. Dark space indicates little influence of a parameter on the model outputs, bright regions reflect strong influence of a parameter and white regions represent sensitivities greater than one.</p
