Dosing-time dependent change in the antitumor effect after CDDP 5 mg/kg i.v. every 7 days at 5:00 or 17:00 in A549 tumor bearing mice. ●: control group, □: CDDP 5:00 treated group, ■: CDDP 17:00 treated group, Arrows: CDDP administrations. Each value represents the mean ± S.E.M. of 9 or 10 mice. **: P < 0.01 (Scheffe’s test). The 17:00 treated group decreased the relative tumor growth compared with the 5:00 treated group. (PPTX 355 kb
