Additional file 6: Figure S4. of Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell
A detailed view of the tail helix region of Cdc48. (A) WebLogo representation [119] of the tail region of different Cdc48 family members. Note that the C-terminal HbYX motif of Cdc48 is not maintained in other family members, with the possible exception of Pex1. (B) The structure of the tail region of Cdc48 (PDB: 3CF1 [43]). In the tail helix (in yellow) of Cdc48, the residue Y755 contacts the sensor 1 residue N624. Unfortunately, the structure of the D2 domain of human nuclear VCP-like (NVL, (PDB ID: 2X8A) does not include the tail helix and therefore it cannot be seen whether its tyrosine also interacts with the Sensor 1 asparagine. (AI 5Â mb
