PCM is funded by a Wellcome Trust Intermediate Fellowship Grant (ref 110110/Z/15/Z).Publisher PDFPeer reviewe

O’Hara, Geraldine A.

McNaughton, Anna L.

Maponga, Tongai

Jooste, Pieter

Ocama, Ponsiano

Chilengi, Roma

Mokaya, Jolynne

Liyayi, Mitchell I.

Wachira, Tabitha

Gikungi, David M.

Burbridge, Lela

O’Donnell, Denise

Akiror, Connie S.

Sloan, Derek

Torimiro, Judith

Yindom, Louis Marie

Walton, Robert

Andersson, Monique

Marsh, Kevin

Newton, Robert

Matthews, Philippa C.

PLoS Neglected Tropical Diseases

CITATION: O'Hara, G. A., et al. 2017. Hepatitis B virus infection as a neglected tropical disease. PLOS Neglected Tropical Diseases, 11(10): e0005842, doi:10.1371/journal.pntd.0005842.The original publication is available at https://journals.plos.org/plosntdsENGLISH ABSTRACT: The Global Hepatitis Health Sector Strategy is aiming for “elimination of viral hepatitis as a public health threat” by 2030 [1], while enhanced elimination efforts for hepatitis are also promoted under the broader remit of global Sustainable Development Goals (SDGs) [2]. This is an enormous challenge for hepatitis B virus (HBV) given the estimated global burden of 260 million chronic carriers, of whom the majority are unaware of their infection [3] (Fig 1). We here present HBV within the framework for neglected tropical diseases (NTDs) [4] in order to highlight the ways in which HBV meets NTD criteria and to discuss the ways in which the NTD management paradigm could be used to strengthen a unified global approach to HBV elimination [5]. The major burden of morbidity and mortality from HBV is now borne by tropical and subtropical countries [6]. Many African populations epitomize specific vulnerability to HBV [7], so we here focus particular attention on Africa, both through focus on the existing published literature and through presentation of a unique data set of opinion and experience (see S1 Supporting Information). However, the themes we represent are transferable to other low- and middle-income settings and are relevant on the global stage.https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0005842#sec001Publisher's versio

O'Hara, Geraldine A.

Chileng, Roma

O'Donnel, Denise

Stellenbosch University SUNScholar Repository

Hepatitis B virus infection as a neglected tropical disease

O'Hara, Geraldine A

McNaughton, Anna L

Liyayi, Mitchell I

Gikungi, David M

O'Donnell, Denise

Akiror, Connie S

Matthews, Philippa C

LSHTM Research Online

Hepatitis B virus infection as a neglected tropical disease.

Geraldine A O'Hara

Anna L McNaughton

Tongai Maponga

Pieter Jooste

Ponsiano Ocama

Roma Chilengi

Jolynne Mokaya

Mitchell I Liyayi

Tabitha Wachira

David M Gikungi

Lela Burbridge

Denise O'Donnell

Connie S Akiror

Derek Sloan

Judith Torimiro

Louis Marie Yindom

Robert Walton

Monique Andersson

Kevin Marsh

Robert Newton

Philippa C Matthews

Directory of Open Access Journals

The outgroup used to root the tree has been omitted. Numbers associated with nodes represent bootstrap/posterior probability; values below 70/0.95 are not shown. Labeled nodes were recovered by all methods and datasets tested (see Materials and Methods). Five major clades are identified by capital letters (A-E). Dashed lines separate 15 smaller subclades. Data on environment, region and ecozone were obtained from published papers or GenBank metadata associated with all available sequences for each species (see also S1 Fig). Unknown information is displayed as empty circles. The arrow points at the representative sequence of Euplotes curdsi sp. nov. The bar represents an inferred evolutionary distance of 5%.</p

Mitchell J. Syberg-Olsen (3339846)

Nicholas A. T. Irwin (3339843)

Claudia Vannini (176507)

Fabrizio Erra (3339840)

Graziano Di Giuseppe (3339849)

Vittorio Boscaro (520131)

Patrick J. Keeling (82468)

The Francis Crick Institute

Maximum Likelihood phylogenetic tree of the genus <i>Euplotes</i> based on SSU rRNA gene sequences (46-sequence dataset, 2140 characters).

Geraldine A. O’Hara

Anna L. McNaughton

Mitchell I. Liyayi

David M. Gikungi

Denise O’Donnell

Connie S. Akiror

Philippa C. Matthews

Crossref

Warwick Research Archives Portal Repository

White Rose Research Online

PCM is funded by a Wellcome Trust Intermediate Fellowship Grant (ref 110110/Z/15/Z)

Hepatitis B virus infection as a neglected tropical disease

Abstract

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