MOESM11 of “Gap hunting” to characterize clustered probe signals in Illumina methylation array data

Abstract

Additional file 11: Figure S34. Filtering on variably methylated probes at various cutoffs in the context of gap signals. We calculated the proportion of gap and non-gap signals at various percentile thresholds of standard deviation cutoff (1–99%) to define a variably methylated probe. Researchers who filter on variable methylation prior to association analysis should be cautioned to be increasingly aware of gap signals (and subsequently their implications on DNAm related to disease described herein) as the cutoff to define a variably methylated probe increases