<p>Sub-groups (early improvement and gradual change) of participants with different trajectories of Work and Social Adjustment Scale (WSAS) change were identified using latent class analyses during the first 6 weeks (marked by vertical line). Score of WSAS greater than 10 suggest significant functional impairment [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0167901#pone.0167901.ref038" target="_blank">38</a>] (horizontal line). * Continuation Phase was limited to CO-MED trial participants who had a clinical response.</p
