<p>The majority of patients (60.7%) had acute lesions in cerebral diffusion-weighted magnetic resonance imaging (DW-MRI) after TAVI. However, there was no association of these acute events (DW-CVEs) and the incidence of SBIs after long-term follow-up. Moreover, DW-CVEs neither aggravated the progression of white matter hyperintensities (> 1.5% / year), nor the progression of cerebral atrophy (> 1% / year). TAVI–Transcatheter aortic valve implantation, DW–diffusion-weighted, CVE–cerebrovascular event, MRI–magnetic resonance imaging, WMH–white matter hyperintensities, TBV–total brain volume, FLAIR—Fluid Attenuated Inversion Recovery.</p