Additional file 1. The number of DP tablets administered to patients according to body weight

Guy Thwaites (155694)

Huynh Quang (3624005)

Jeremy Farrar (74677)

Le Dong (3421448)

Marcel Wolbers (33689)

Ngo Thanh (3638014)

Nguyen Nha-Ca (3638026)

Nguyen Thuy-Nhien (3638020)

Nguyen Tong (3638017)

Nguyen Tuyen (3638023)

Nicholas White (17236)

Tran Hien (3421469)

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MOESM1 of Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisininâpiperaquine in the south of Vietnam

Background Artemisinin resistant Plasmodium falciparum has emerged in the countries of the Greater Mekong sub‑region posing a serious threat to global malaria elimination efforts. The relationship of artemisinin resistance to treatment failure has been unclear. Methods In annual studies conducted in three malaria endemic provinces in the south of Vietnam (Binh Phuoc, Ninh Thuan and Gia Lai) between 2011 and 2015, 489 patients with uncomplicated P. falciparum malaria were enrolled in detailed clinical, parasitological and molecular therapeutic response assessments with 42 days follow up. Patients received the national recommended first‑line treatment dihydroartemisinin‑piperaquine for three days. Results Over the 5 years the proportion of patients with detectable parasitaemia on day 3 rose steadily from 38 to 57% (P < 0.001). In Binh Phuoc province, the parasite clearance half‑life increased from 3.75 h in 2011 to 6.60 h in 2015 (P < 0.001), while treatment failures rose from 0% in 2012 and 2013, to 7% in 2014 and 26% in 2015 (P < 0.001). Recrudescence was associated with in vitro evidence of artemisinin and piperaquine resistance. In the treatment failures cases of 2015, all 14 parasite isolates carried the C580Y Pfkelch 13 gene, marker of artemisinin resistance and 93% (13/14) of them carried exoE415G mutations, markers of piperaquine resistance. Conclusions In the south of Vietnam recent emergence of piperaquine resistant P. falciparum strains has accelerated the reduced response to artemisinin and has led to treatment failure rates of up to 26% to dihydroartemisinin‑piperaquine, Vietnam’s current first‑line ACT. Alternative treatments are urgently needed

Thanh, Ngo V.

Thuy-Nhien, Nguyen

Tuyen, Nguyen T.K.

Tong, Nguyen T.

Nha-Ca, Nguyen T.

Dong, Le T.

Quang, Huyn H.

Farrar, Jeremy

Thwaites, Guy

White, Nicholas

Wolbers, Marcel

Hien, Tran T.

Oxford University Research Archive

English

Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin-piperaquine in the south of Vietnam

https://figshare.com/articles/MOESM1_of_Rapid_decline_in_the_susceptibility_of_Plasmodium_falciparum_to_dihydroartemisinin_piperaquine_in_the_south_of_Vietnam/4551970

MOESM1 of Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisininâpiperaquine in the south of Vietnam

Abstract

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MOESM1 of Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisininâpiperaquine in the south of Vietnam

Abstract

Similar works

Full text

Available Versions

FigShare

Oxford University Research Archive

MOESM1 of Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisininâpiperaquine in the south of Vietnam