<p>Administration of rAPC 20 minutes after the injury significantly improves locomotor performance of wild-type mice (A), starting from 14 days post injury, to an extent comparable to that of the injured PAR-1 null mice receiving no APC treatment. However, APC shows no additional benefit of functional improvements in injured PAR-1 null mice (B), suggesting that the effectiveness of APC is associated with PAR-1. (n = 10/genotype, means ± SEM, 2-way ANOVA,*p < 0.05, **p < 0.01).</p
