<p><b><i>Background:</i></b> The value of chronic kidney disease (CKD)
screening in the general population remains unclear but may be
beneficial in populations with high disease prevalence. We examined risk
factors for albuminuria among participants in a state-wide CKD
screening program in Hawaii. <b><i>Methods:</i></b> The National Kidney
Foundation of Hawaii Kidney Early Detection Screening (NKFH-KEDS)
program held 19 CKD screening events from 2006 to 2012. Participants
rotated through 5 stations during which sociodemographic, blood glucose,
urine albumin-to-creatinine ratio (ACR), and spot urine albumin data
were collected. Multivariate logistic regression analyses (adjusted for
age, sex, race/ethnicity, body mass index [BMI]) were used to identify
clinical predictors of abnormal ACR (≥30 μg/mg) and abnormal spot urine
albumin (>20 mg/L) levels. <b><i>Results:</i></b> Among 1,190
NKFH-KEDS participants who met eligibility criteria, 13 and 49% had
abnormal ACR and urine albumin levels, respectively. In multivariate
logistic regression analyses, participants of older age (>65 years),
Asian and Pacific Islander race/ethnicity, BMI ≥30 kg/m<sup>2</sup>, and
with hypertension had higher risk of abnormal ACR. Being of older age;
Asian, Pacific Islander, and Mixed race/ethnicity; and having diabetes
was associated with higher risk of abnormal urine albumin levels in
adjusted analyses. <b><i>Conclusions:</i></b> NKFH-KEDS participants of
older age; Asian and Pacific Islander race/ethnicity; and with obesity,
hypertension, and diabetes had higher risk of kidney damage defined by
elevated ACR and urine albumin levels. Further studies are needed to
determine whether targeted screening programs can result in timely
identification of CKD and implementation of interventions that reduce
cardiovascular disease, death, and progression to end-stage renal
disease.</p