Clinical, physiological, and molecular biological data from infants admitted to emergency department (ED) with physician-diagnosed bronchiolitis and positive for RSV.<br><br>Nasal wash samples collected (one from each infant) and analyzed for 1) RSV gene copy numbers (genes NS1, NS2, N, G, F) and host RNase P copy number by qPCR, 2) cytokine levels by multiplex human cytokine assay, and 3) biomarker levels (caspase, LDH, MMP-7, MPO) by specific assay kits.<br><br>Infants were enrolled in study after
obtaining written informed consent from a parent or legal guardian, and met all
the inclusion criteria and none of the exclusion criteria. The inclusion
criteria were the child was previously healthy and had a physician diagnosis of
bronchiolitis in the ED. The exclusion criteria were co-morbid medical
conditions such as chronic lung disease, cyanotic congenital heart disease,
neuromuscular disease, a primary immunodeficiency, prematurity (<36 weeks)
or had respiratory distress unrelated to a viral URI. This study was approved
by the Institutional Review Board (IRB) of Human Subject Research at Baylor
College of Medicine and Affiliated Institutions which includes Texas’s Children
Hospital. The IRB is registered with the Office for Human Research Protections
of the U.S. Department of Health and Human Services. All personal identifying information have been removed from the data set. <br>
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