Efficient copper-catalyzed N-arylation of NH-containing heterocycles and sulfonamides with arenediazonium tetrafluoroborates

Abstract

<p>A practical copper-catalyzed N-arylation of NH-containing heterocycles with arenediazonium tetrafluoroborates has been developed using CuCl as catalyst and K₂CO₃ as additive under ligand-free conditions. This reaction system has wide substrate scope including imides, 1<i>H</i>-pyrazole, 1<i>H</i>-tetrazoles, 1,2-benzisothiazol-3(2<i>H</i>)-one, and related sulfonamides and gives moderate to excellent yields (up to 95%) of the desired products. This strategy is very general, simple, environmentally friendly, and tolerant of oxygen.</p