The Moravian Church's monthly journal of its worldwide activities, including in Labrador, published from 1819-94

Hoang Nguyen (179257)

In Hwang (3561575)

Minh Nguyen (694574)

MinKyun Na (1378326)

Phuong Thuong (3904684)

Thi Hoang (3904681)

Thuy Nguyen (160049)

BMC Complementary and Alternative Medicine

PubMed

Abstract Background The medicinal plant Siegesbeckia orientalis L. has been commonly used for the treatment of acute arthritis, rheumatism, and gout in Vietnam. However, pharmacological research of this plant associated with gout has not been reported. Anti-hyperuricemic and anti-inflammatory effects were evaluated and observed for the crude ethanol extract (CEE) of S. orientalis. Retention of these biological properties was found in a n-butanol-soluble fraction (BuOH fr.) of the extract, and therefore further biological and chemical investigations were undertaken on the BuOH fr. to support the medical relevance of this plant. Methods The aerial part of S. orientalis was obtained in the mountainous region of Vietnam. The crude ethanol extract (CEE) and its BuOH fr. were prepared from the plant materials. Anti-hyperuricemic activities of the CEE and BuOH fr. were tested in vivo using the model oxonate-induced hyperuricemia rats through determination of serum uric acid levels and inhibitory effects on xanthine oxidase (XO) in the rat liver. Anti-inflammatory activities of the BuOH fr. were also evaluated in vivo using carrageenan-induced paw edema and urate-induced synovitis in rats. Active components of the BuOH fr. were characterized by comparison of HPLC retention time (t R) and spectroscopic data (UV, 1H–NMR) with those of reference compounds. Results The CEE of S. orientalis displayed anti-hyperuricemic activity, and the BuOH fr. was found to be the most active portion of the extract. Further in vivo studies on this fraction showed 31.4% decrease of serum uric acid levels, 32.7% inhibition of xanthine oxidase (XO), 30.4% reduction of paw edema volume, symptomatic relief in urate-induced synovitis and significant analgesic effect at the dose of 120 mg/kg, as compared to the corresponding values of the control groups. Chemical analysis of the BuOH fr. revealed high phenolic content, identified as caffeic acid analogues and flavonones. Conclusions This study suggested that anti-hyperuricemic and anti-inflammatory mechanism of S. orientalis is related to XO inhibitory effect of the phenolic components. Our findings support the use of this plant as the treatment of gout and other inflammatory diseases

Thuy Duong Nguyen

Phuong Thien Thuong

In Hyun Hwang

Thi Kim Huyen Hoang

Minh Khoi Nguyen

Hoang Anh Nguyen

MinKyun Na

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Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content

Memorial University Newfoundland Digital Archive Initiative

Nachrichten aus der Brüder-Gemeine, 1834, no. 04

Report on toxicity study of BuOH fraction. (DOCX 104Â kb

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Additional file 2: of Anti-Hyperuricemic, Anti-Inflammatory and Analgesic Effects of Siegesbeckia orientalis L. Resulting from the Fraction with High Phenolic Content

http://dx.doi.org/10.1186/s12906-017-1698-z

Nachrichten aus der Brüder-Gemeine, 1834, no. 04

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Directory of Open Access Journals

Memorial University Newfoundland Digital Archive Initiative

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