Calculation of attributable risk fraction and population attributable risk fraction of TB. (DOC 63 kb

Chien-Chang Lee (235742)

Chih-Cheng Lai (533198)

Chun-Wei Wu (525242)

I-Lin Wu (4004855)

Jiunn-Yih Wu (575109)

Meng-Tse Lee (2282011)

Shy-Shin Chang (56324)

Yi-Wen Tsai (423938)

BMC Pulmonary Medicine

Abstract Background Mycobacterium tuberculosis (TB) is one of the world’s most devastating public health threats. Our goal is to evaluate whether the use of non-steroidal anti-inflammatory drugs (NSAIDs) affect the risk of new incident active TB disease. Methods We conducted a nested case-control analysis by using a 1 million longitudinally followed cohort, from Taiwan’s national health insurance research database. Effects of NSAIDs on active TB were estimated by conditional logistic regression and adjusted using a TB-specific disease risk score (DRS). NSAIDs exposures were defined as having a prescription record of NSAIDs ≧ 7 days that ended between 31 and 90 days prior to the index date. Results A total of 123,419 users of traditional NSAIDs, 16,392 users of cyclooxygenase-2 selective inhibitor (Coxibs), and 4706 incident cases of active TB were identified. Compared with nonusers, use of traditional NSAIDs was associated with an increased risk of TB in the unadjusted analysis ([RR], 1.39; 95% [CI], 1.24 – 1.57 and DRS adjusted analysis ([ARR], 1.30; 95% [CI], 1.15– 1.47). However, use of Coxibs was not associated with a significant increase in the risk of TB after DRS adjustment ([ARR], 1.23; 95% [CI], 0.89 – 1.70). Conclusions In this large population-based study, we found that subjects using traditional NSAIDs were associated with increased risk for active TB. We did not find evidence for a causative mechanism between traditional NSAIDs and TB, and more research is required to verify whether the association between traditional NSAIDs and TB is causal, or simply reflects an increased use of anti-inflammatory drugs in the early phases of TB onset

Chun-Wei Wu

Jiunn-Yih Wu

Meng-Tse Gabriel Lee

Chih-Cheng Lai

I-Lin Wu

Yi-Wen Tsai

Shy-Shin Chang

Chien-Chang Lee

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Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study

https://figshare.com/articles/Additional_file_2_of_Risk_of_incident_active_tuberculosis_disease_in_patients_treated_with_non-steroidal_anti-inflammatory_drugs_a_population-based_study/4976543

Additional file 2: of Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study

Additional file 2: of Risk of incident active tuberculosis disease in patients treated with non-steroidal anti-inflammatory drugs: a population-based study

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