Comparison of [<sup>18</sup>F]FEPPA regional total distribution volume (<i>V</i><sub><i>T</i></sub>) between healthy control subjects and AD patients calculated with PBIF75 for HABs (left) and MABs (right).
<p>(<i>cf</i>. figure 1 in ref [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0177785#pone.0177785.ref007" target="_blank">7</a>]). PBIF75 estimation led to the same conclusion as the previously published with ASIF: [<sup>18</sup>F]FEPPA <i>V</i><sub><i>T</i></sub> in AD patients is on average 13–48% higher than HC (A Factorial ANOVA with genotype and age as covariate showed: p<0.05 in the Temporal, Prefrontal, Parietal and Occipital and p = 0.4 in the hippocampus). Images were partial volume effect corrected prior to TAC extraction. * p< 0.05 in ANOVA within group.</p
