Detection of Promoter DNA Methylation of <i>APC</i>, <i>DAPK</i>, and <i>GSTP1</i> Genes in tissue Biopsy and Matched Serum of Advanced-Stage Lung Cancer Patients
<p>Promoter DNA hypermethylation of <i>APC, DAPK</i>, and <i>GSTP1</i> genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, and 30% of controls were positive for <i>APC, DAPK</i>, and <i>GSTP1</i> hypermethylation respectively. We couldn't find any significant role of DNA hypermethylation in lung cancer. However, long follow-up of methylation positive controls will be required to confirm its role for the prediction of lung cancer.</p
