Copper-Catalyzed Cross-Dehydrogenative <i>N</i>²‑Coupling of <i>NH</i>-1,2,3-Triazoles with <i>N</i>,<i>N</i> -Dialkylamides: <i>N</i>‑Amidoalkylation of <i>NH</i>-1,2,3-Triazoles

Abstract

An efficient copper-catalyzed C–N bond formation by N–H/C–H cross-dehydrogenative coupling (CDC) between <i>NH</i>-1,2,3-triazoles and <i>N</i>,<i>N</i>-dialkylamides has been developed. The method provided <i>N</i>-amidoalkylated 1,2,3-triazoles with moderate to high yields, and the reactions showed high <i>N</i>²-selectivities when 4,5-disubstituted <i>NH</i>-1,2,3-triazoles served as the substrates