Additional file 4: Figure S4. Comparison of standardized differences (A, B) and propensity scores (C, D) in unmatched and matched samples. A, C: propensity score matching in overall dataset; B, D: propensity score matching of dataset excluding deaths with other reasons

Jian  Sun (1234941)

Rui Sun (177521)

Zheyu Hu (4055104)

Zhongying Huang (4055101)

Journal of Translational Medicine

Abstract Background There is ongoing debate about surgery of primary site in nasopharyngeal carcinoma patients. Methods 3919 patients with nasopharyngeal carcinoma identified in the SEER registry between 2004 and 2013. The benefit of surgery of primary nasopharynx tumor site on overall and cancer-specific survival was assessed by risk-adjusted multivariate Cox proportional hazard regression and propensity score matching modeling. Results Surgery was marginally associated with better overall survival (hazard ratio (HR) = 0.816, 95% CI 0.656–1.015, p = 0.07) and cancer-specific survival (HR = 0.749, 95% CI 0.552–1.018, p = 0.06) in the propensity score model. Among 398 cases who underwent primary site surgery, 282 (70.85%) received local tumor excision and 79 (20.31%) received pharyngectomy. Local tumor excision and pharyngectomy had almost the same effect on survival in propensity score matching analysis. The benefit was significant in subgroups of white, age <60 year, and patients with T3, N1, M0, AJCC stage III, or moderately differentiated tumors. Further survival analysis showed surgery to promote survival in both radiotherapy and non-radiotherapy patients. Conclusion This is the first population-based analysis using propensity score model to provide evidence of a positive impact of surgery on survival in nasopharyngeal carcinoma. Moreover, surgery demonstrated the significant benefit in subgroups of patients with specific clinical characteristics

Jian Sun

Zhongying Huang

Zheyu Hu

Rui Sun

Directory of Open Access Journals

Benefits of local tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database

Additional file 5: Figure S5. Kaplan Meier Curve for all-cause mortality (A) and nasopharyngeal carcinoma-specific mortality (B) stratified by surgery. Table S6. Survival rate information for all cause mortality stratified by surgery. Table S7. Survival rate information for nasopharyngeal carcinoma-specific mortality stratified by surgery

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MOESM5 of Benefits of local tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database

MOESM4 of Benefits of local tumor excision and pharyngectomy on the survival of nasopharyngeal carcinoma patients: a retrospective observational study based on SEER database

Anonymous

Galiciana