Forrest plot of the risk ratio for the association of MTA1 and OS in DTC patients:Association between MTA1 overexpression and 5-year (6a) OS in high-quality studies subgroup. Association between MTA1 overexpression and 5-year (6b) OS in gastrointestinal cancer subgroup. Association between MTA1 overexpression and 5-year (6c) OS in esophageal cancer subgroup</p

Bo Chen (1234734)

Guo-dong Cao (3044901)

Mao-ming Xiong (3044898)

ObjectivesMetastasis-associated protein 1 (MTA1) is a transcriptional regulator and significantly associated with prognosis of patients with cancer. However, its role as a potential prognostic marker in digestive tract cancer (DTC) is controversial. In this study, a meta-analysis was conducted to evaluate the MTA1 expression as a predictor of clinicopathology and survival of patients with DTC.MethodsWe searched PubMed, Ovid, Web of Science and Cochrane databases using multiple search strategies for eligible studies. STATA 11.0 software was used to pool the data and analyze the association, odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the strength of the association. Furthermore, the Newcastle-Ottawa scale was used to evaluate the quality of eligible studies.ResultsMTA1 overexpression was strongly associated with depth of invasion (OR = 1.88, 95%CI: 1.05-3.37, P = 0.03), lymph node metastasis (OR = 2.30, 95%CI: 1.76-3.01, PConclusionsMTA1 expression is strongly correlated with metastasis-related variables, and represents a promising prognostic factor in DTC

Guo-Dong Cao

Bo Chen

Mao-Ming Xiong

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PLoS ONE

Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis.

<div>ObjectivesMetastasis-associated protein 1 (MTA1) is a transcriptional regulator and significantly associated with prognosis of patients with cancer. However, its role as a potential prognostic marker in digestive tract cancer (DTC) is controversial. In this study, a meta-analysis was conducted to evaluate the MTA1 expression as a predictor of clinicopathology and survival of patients with DTC.MethodsWe searched PubMed, Ovid, Web of Science and Cochrane databases using multiple search strategies for eligible studies. STATA 11.0 software was used to pool the data and analyze the association, odds ratios (ORs) and 95% confidence intervals (CIs) were used to measure the strength of the association. Furthermore, the Newcastle-Ottawa scale was used to evaluate the quality of eligible studies.ResultsMTA1 overexpression was strongly associated with depth of invasion (OR = 1.88, 95%CI: 1.05–3.37, P = 0.03), lymph node metastasis (OR = 2.30, 95%CI: 1.76–3.01, P<0.001), vascular invasion (OR = 2.02, 95%CI: 1.40–2.91, P<0.001) and TNM stage (OR = 2.78, 95%CI: 1.63–4.74, P<0.001), and was related to 1- (RR = 1.84, 95%CI: 1.18–2.89, P = 0.008), 3- (RR = 1.74, 95%CI: 1.32–2.30, P<0.001) and 5-year (RR = 1.64, 95%CI: 1.18–2.27, P = 0.003) OS. Further, MTA1 was associated with 1- (RR = 4.16, 95%CI: 1.35–12.81, P = 0.01), 3- (RR = 1.90, 95%CI: 1.02–3.53, P = 0.04) and 5- (RR = 2.17, 95%CI: 1.41–3.32, P<0.001) year DFS. In subgroup analyses based on study quality and tumor type, MTA1 overexpression was obviously related to clinical parameters, such as lymph node metastasis and TNM stage, and was also associated with prognosis of patients with gastrointestinal or esophageal cancer.ConclusionsMTA1 expression is strongly correlated with metastasis-related variables, and represents a promising prognostic factor in DTC.</div

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Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis

Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis - Fig 6

Begg’s funnel plot (7a) (P = 0.35) and Egger’s funnel plot (7b) (P = 0.13) for possible publication bias test of this study. There was no publication bias and the results are credible</p

Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis - Fig 7

https://figshare.com/articles/Role_of_metastasis-associated_protein_1_in_prognosis_of_patients_with_digestive_tract_cancers_A_meta-analysis/5058844

Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis - Fig 6

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