Fecal shedding of MAdV-2 is increased in mice expressing functional enteric α-defensins.

Abstract

<p>Data are viral genomes per fecal pellet at the indicated times post infection for each wild type (solid black lines) or <i>Mmp7</i>^{<b><i>-/-</i></b>} mouse (grey dashed lines) after oral infection with (A and B) 1x10⁷ infectious units/mouse or (C and D) 1x10⁶ infectious units/mouse of wild type MAdV-2. Dashed black line in A and C indicates the limit of detection. (B and D) Total virus shed per mouse was calculated by log-transforming the data and determining the area under the curve (AUC) for the time range indicated in A and C for each mouse. N = 7–10 mice per group. In scatter plots, lines are mean ± SD. *P<0.05.</p