Additional file 1: Supplemental figures. of Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics

Abstract

Figure S1. Immunocytochemical characterization of WD iPSCs. Figure S2. STR DNA analysis of WD fibroblasts, iPSCs, and NSCs. Figure S3. LysoTracker staining and Nile red staining of LDL loaded NSCs. Figure S4. HT144B NSCs show increased LysoTracker staining. Figure S5. Chemical structures. Figure S6. DT and HPBCD treatment reduces lysosomal staining in HT144B NSCs. Figure S7. DT and HPBCD do not significantly reduce neutral lipid accumulation in WD NSCs. Figure S8. High concentrations of DT and HPBCD affect cell viability. Figure S9. DT and HPBCD combination treatment have an additive effect on reducing lysosomal staining in HT144B NSCs. (PDF 652 kb

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