<p>Panels show B-CLL cell cytotoxicity with the autologous patient serum (PS) from patients 1–5, respectively, in comparison with cytotoxicity using NHS. Cytotoxicity was induced in the presence of RTX plus the addition of either CFH mAb7968 (α-CFH) or isotype-matched negative control antibody 7B2 (α-Con). For each patient and serum type, the mean percent CDC in the presence of the αCFH antibody was divided by the mean percent CDC in the presence of the αCon antibody to obtain "fold cytotoxicity". The p values of the difference between response in PS vs. NHS are shown on the figure. The p values for fold cytotoxicity as a result of α-CFH addition compared to α-Con addition were 0.00017, 0.00060, n.s., n.s., n.s in PS, and 0.00016, 0.00021, 0.000012, 0.00001, and 0.00025 in NHS, for patients 1–5 respectively (n.s = not significant).</p
