A20 restricts interleukin (IL)-23 signal to IL-17 producing cells.

Abstract

<p>(A) Thickness of IL-23- or BSA-treated ears in A20^+/- and A20^+/+ littermate mice. Data are representative of two experiments. Error bars represent SEM; N = 3 (male, BSA injected group) or 9 (1 male and 8 female of A20^+/- mice, and 2 male and 7 female of A20^+/+ mice for IL-23-injected group) for each group,*<i>p</i> < 0.05 compared to IL-23-treated A20^+/+ mice by Student’s <i>t</i>-test. (B) Numbers of TCRγδ⁺, TCRαβ⁺, IL-17⁺ TCRγδ⁺, and IL-17⁺ TCRαβ⁺ T cells from ear-draining lymph nodes from IL-23-treated or BSA-treated mice of indicated genotypes. Data are representative of two experiments. Error bars represent SEM; N = 3 (male, BSA-injected group) or 9 (1 male and 8 female of A20^+/- mice, and 2 male and 7 female of A20^+/+ mice for IL-23-injected group) for each group, *<i>p</i> < 0.05 compared to IL-23-treated A20^+/+ mice by Student’s <i>t</i>-test.</p